So far, 11 House members have lost their primaries, including seven Republicans and four Democrats, with 10 of the incumbents being ousted as they faced off against a colleague due to redistricting, according to Axios. In 2020, 13 House incumbents lost their seats, the most primary election losses in a non-redistricting year since 1974.

Rep. Sean Casten (D-IL) secured the Democratic nomination against his rival progressive incumbent Rep. Marie Newman (D-IL) after a majority of Newman's district fell into Casten's due to the state's redrawn maps. Illinois lost a congressional seat for the first time in over 200 years after the 2020 U.S. census showed a population decline.

Several incumbents faced tough primary races as former President Donald Trump endorsed their opponents. Rep. Peter Meijer (R-MI) was defeated by John Gibbs, a former senior official in the Department of Housing and Urban Development during the Trump administration, in the Republican primary for Michigan’s 3rd Congressional District.